I did research in the computational laboratory of Mona Singh at Princeton University. I focused on understanding how DNA alterations affect proteins and tissues and ultimately lead to disease.
We discovered patterns of mutations in uterine and
colorectal cancers and melanoma that occur at specific
positions in zinc finger domains. These mutations affect
hundreds of DNA-binding proteins, and our statistical
investigations suggest potential roles in dysregulation in
PubMed | PubMed Central | PLOS Comp Bio
We developed a framework for finding genes whose
expression correlates with tissue morphology features. By
applying it to large collections of paired clinical sample
data, we can identify potential new functional categories
for genes while using existing annotations to characterize
observable tissue features.
Submitted, with J. Ash, G. Darnell, and B. Engelhardt.
We are developing a method to understand and predict the
degree of impact of amino acid substitutions on protein
function. We combine homologous sequence alignments with
experimental mutagenesis data to create an interpretable
model of substitution effect.
In preparation, with Mona Singh.